The New England Patriots will have a painful reminder of their epic Super Bowl loss from the 2008 season that ended 1 game short of perfection as they meet the New York Giants in the final preseason NFL betting game for both teams at the new Meadowlands Stadium. Kick-off is set for 7:05pm EST and the game can be seen live on the NFL Network. Online sportsbooks have opened with the Giants -3 favorites in NFL preseason week 4 picks at home vs the Patriots with and an over/under total of 38. The New England Patriots have a preseason record of 2-1 both straight up and against the spread with all 3 games having gone OVER the betting total.

In the final match-ups of 2010 NFL preseason predictions, Thursday will feature the New York Jets vs Philadelphia Eagles at 7:30pm EST from Lincoln Financial Field and the Denver Broncos vs Minnesota Vikings at 8:00pm EST from Mall of America Field. New York has gone 1-2 in NFL preseason betting while Philadelphia has had better success going 2-1. Denver has also had a slow start heading into week 4 odds while Brett Fave and Minnesota has gone 2-1. Online sportsbooks have the Eagles -1.5 favorites at home vs the Jets with an over/under total of 34 while the Vikings -4.5 are also favored at home vs the Broncos with an over/under total of 35.5.

The final week of 2010 NFL preseason betting will begin on Thursday with all 32-team taking the field in final preparations for the regular season which will begin September 9th. The Buffalo Bills gave gone 2-1 in NFL preseason odds and will hit the road to face the Detroit Lions who are also 2-1 from Ford Field at 6:35pm EST while the New England Patriots (2-1) will try to close out week 4 of the NFL preseason at New Meadowlands Stadium with a win vs the New York Giants at 7:00pm EST who are looking to break the .500 after going 1-2 in the first three weeks. Online sportsbooks have Detroit -4 favorites at home with a betting total of 38.5 while the Giants -3 are also favored at home in week 4 NFL preseason picks with an over/under total of 37.5.