FedEx Field Washington, DC is the site for the biggest game of week 1 college football betting odds and the biggest in Boise State history as the #3 Broncos matchup with the Virginia Tech Hokies, a perennial contender in the Atlantic Coast Conference. Kick-off is schedule for 8:00pm EST Monday for the ESPN broadcast and online sportsbooks have opened with Virginia Teach as 1.5-point favorites in college football predictions with an over/under betting total of 52. Boise State has the once in a lifetime opportunity to make the BCS Championship game but must win this tough opener and run the table. The Broncos have gone from a Cinderella story to a powerful national favorite in college football odds.

A phenomenal week 2 of college football betting action begins with a key SEC showdown on ESPN as Mississippi State hosts Auburn at 7:30pm EST on ESPN. Both teams are coming off impressive wins last week and online sportsbooks have opened with the Tigers -3. The key to this week 2 game may come down to the shaky Auburn defense being able to tighten up. Friday features an ESPN double header on the college football week 2 schedule starting with a huge intra-state match-up of Marshall hosting West Virginia at 7:00pm EST on ESPN. This will be the home debut of new coach Doc Holliday, who was a key assistant and recruiter for West Virginia before taking the job with the Thundering Herd. Holliday is hoping for a far better performance than the one he got last week in a blowout loss at Ohio State but the WVU is a Big East favorite and a 13-point favorite in college football odds.

A fading program and coach will start off their season against a program and coach on the rise from M&T Bank Stadium in Baltimore as the Maryland Terrapins meet the Navy Midshipmen at the home of the NFL Ravens. Kick-off is scheduled for 4:00pm EST for the game that can be seen on ESPN. Online sportsbooks have opened with Navy -6 in college football betting picks with an over/under total of 48.5. Ralph Friedgen begins his 10th season at his Alma Mater as a dead man coaching. “The Fridge” and his Terrapins slipped to a horrific 2-10 college football betting season after an 8-5 bowl campaign in 2008. The Terps return 7 starters on offense and 5 on defense.

A potential major upset in college football odds is not out of the question nor is a Texas shootout as the Texas Tech Red Raiders host the SMU Mustangs on Sunday. Kickoff is at 3:30pm EST for the game that can be seen on ESPN. Online sportsbooks have opened with of Texas Tech -13.5 favorites with a betting total of 58. SMU made a huge leap in head coach June Jones’ second year on the job as they went from 1-11 in college football picks to an 8-5 bowl team that defeated Nevada in the Hawaii Bowl 45-10 for their first post season appearance since returning to action in 1989 after the NCAA” Death Penalty.”

The 2010 college football betting opening weekend will feature the rematch of the 2008 Conference USA Championship game as the back-to-back defending champion East Carolina Pirates will host the Tulsa Golden Hurricane. Kick-off is set for 2:00pm EST and the game can be seen on ESPN2. Online sportsbooks opened with Tulsa as an 7-point favorite in college football predictions with an over/under total of 57. Tulsa head coach Todd Graham went 10-4 and 11-3 in his first two seasons before stepping back to 5-7 in college football odds last year. But with 9 starters returning on offense led by junior QB GJ Kinne the Golden Hurricane is primed for a return to contention in CUSA.

The Cincinnati Bearcats will begin the new Butch Jones era as they meet a Fresno State Bulldog team set to leave the Western Athletic Conference for the Mountain West at the end of this year. Kick-off tonight is schedule for 10:05pm EST for the game that can be seen on ESPN2. Online sportsbooks have opened with Fresno State as a 2.5-point college football betting favorite in week 1 odds with an over/under total of 55.5. These two teams met last year at Cincinnati and the Bearcats scored a 28-20 win but failed to cover as 17-point favorites in college football odds. Fresno State actually outgained the Bearcats and had almost 44 minutes time of possession.

A dream season looks ruined before it has even begun while a coach on the hot seat may find it is considerably cooler by the end of tonight. The 18th ranked North Carolina Tar Heels will meet the #21 LSU Tigers at the Georgia Dome in the kick-off classic. The game can be seen at 8:05pm EST on ABC and LSU has opened at online sportsbooks as a 8-point favorite in college football predictions with an over/under betting total of 43. The money line has opened with LSU at -340 in college football lines for week 1 while North Carolina is listed as a +270 underdog. The reason that the lower ranked team is such a big favorite is that North Carolina’s roster is now decimated due to suspensions and potential ineligibility issues due to an academic fraud case that blew wide open last week.

The 6th ranked TCU Horned Frogs will meet the #24 Oregon State Beavers at Cowboys Stadium in Arlington Texas in college football week 1 odds for a key inter-conference opener that will have long term BCS championship game implications. Kick-off on ESPN is scheduled for 7:50pm EST and TCU has opened at online sportsbooks as a 13-point college football betting favorite with an over/under total of 50. It is “BCS Title or Bust” for the Horned Frogs this year as they had a perfect 12-0 regular season last year before a Fiesta Bowl loss to Boise State. TCU is determined to show that they belong in the same class as the big boys as they were not happy about being matched up with Boise State and yet let down and lost the game after complaining that they deserved a shot against a high profile powerhouse.

The Nebraska Cornhuskers will kick-off their final season as a member of the Big 12 Conference tonight when they host a non-league tune up game against the Western Kentucky Hilltoppers, who went 0-12 in college football picks last year. The 8th ranked Cornhuskers, as expected, opened at online sportsbooks as a whopping 39.5-point favorite in week 1 college football odds with the over/under total at 52.5. Kickoff is at 7:05 PM Eastern. Nebraska is one of the favorites to win the Big 12 and also a top choice to compete for the BCS championship. The Huskers have a loaded offense with 9 starters returning led by seniors Zac Lee at QB and Roy Helu at running back.

Mississippi State will enter the 2010 college football betting season with momentum and enthusiasm after a better than expected 2009 as they entertain the Memphis Tigers in the opener for both teams. Kick-off is scheduled for 7:00pm EST and the game can be seen on ESPNU. Online sportsbooks have opened with Mississippi State as a 21-point favorite in college football lines with a total of 48. The Memphis Tigers look to be rebuilding in 2010 with 25 lettermen gone and a new sophomore QB in Cannon Smith. The offense has 7 returning starters and averaged 22 points per game last year. The defense returns 6 starters to a unit that allowed 35 PPG.