NFL Lines Week 1: Cardinals vs Rams - NFL Betting Odds

The Arizona Cardinals and the St. Louis Rams will both be looking to go 1-0 on the season when they meet at the Edward Jones Dome on Sunday at 4:15pm EST. Online sportsbooks have the Cardinals listed as 4-point favorites in NFL lines for week 1 vs the Rams while the over/under total is sitting at 39. Heading into week 1 NFL betting odds, the Cardinals went 10-6 straight up last season and 9-7 against the spread while the Rams went a woeful 1-15 straight up but did better covering the spread going 7-9. Arizona will enter their season opener after going 5-5 when playing September last season, 6-4 when playing on turf and 8-2 when playing within their division.

Despite the distraction and controversy surrounding the removal of QB Matt Leinart, the Cardinals still went 3-1 in NFL lines during the preseason with wins over the Houston Texans, Chicago Bears and Washington Redskins with their only loss coming in week 2 vs the Tennessee Titans. Derek Anderson threw for 334-yards on 56 attempts with two touchdowns and two interceptions while Beanie Wells rushed for 75-yard on 27 attempts. Arizona went 5-0 straight up last season for their last 5 games when playing St. Louis, 7-3 straight up in their last 10 games on the road and 5-0 straight up in their last 5 games when playing on the road against the Rams while the over/under total has gone UNDER in 4 of the Cardinals last 5 games when playing the Rams.

Despite being underdogs in NFL lines to win the 2011 Super Bowl or even to even make the playoffs, St. Louis also went 3-1 during the preseason losing in week 1 to the Minnesota Vikings but stormed back to defeat the Cleveland Browns, New England Patriots and Baltimore Ravens. QB Sam Bradford threw 33-55 for 338-yards with three touchdowns during the preseason while Steven Jackson saw limited actions with 9 carries for 42-yards. The Rams went 0-10 in NFL lines last year when playing in September, 1-9 when playing on turf, and 0-10 when playing within the division. St. Louis went 2-4 against the spread in their last 6 games when playing at home against Cardinals and 2-4 ATS in their last 6 games overall.