NFL Week 10 Betting Predictions - New England Patriots at Indianapolis Colts

One of the best rivalries in NFL week 10 betting is highlighted on NBC’s Sunday night football as the unbeaten Indianapolis Colts (8-0) host the New England Patriots (6-2). Peyton Manning and Tom Brady are two of the best quarterbacks for betting on NFL predictions and usually when their two teams meet the games are good. Brady and the Patriots have won five of the seven regular season meetings against Manning and the Colts. The Colts are 8-0 straight up, 4-4 against the spread in NFL betting and are 10-0 when playing on turf. Indianapolis is a 3-point favorite with a total of 49.5 at online sportsbooks.

The Colts have won their last 17 regular season games in NFL predictions dating back to last season. The Patriots have won their last three and have been very impressive, winning by a combined 121-24. Brady threw for 332 yards last week and now the Patriots have won 14 straight games and 25 of 27 all-time when Brady throws for 300 yards or more. The Colts survived last week when Houston’s Kris Brown missed a game-tying 42-yard field goal at the buzzer. The Colts are one of two remaining unbeaten teams this season with the Saints being the other.

This Sunday night football game features the two top passing offenses in the NFL and the two top defenses in terms of fewest points allowed. The Colts defense may start to slip though since they are dealing with quite a few injuries. Safety Bob Sanders is out for the season and a number of other starters are hurt on the defense side of the ball. Matt Schaub threw for over 300 yards against the Colts last week so Brady could have a big night. The Patriots hold a 42-27 edge in NFL betting predictions for their all-time regular season series with the Colts but they lost 18-15 at Indianapolis a year ago.

The Patriots are 5-2 ATS in their last 7 games as a road underdog. The Patriots are 8-3 ATS in their last 11 meetings in Indianapolis. The Colts are 5-2 ATS in their last 7 games overall. The Colts are 4-10 ATS in their last 14 home games. The Under is 4-0 in the Patriots last 4 road games heading into week 10 NFL betting. The Under is 5-2 in the Patriots last 7 games overall. The Under is 4-0 in the Colts last 4 games in November. The Under is 4-1 in NFL odds the Colts last 5 home games. The Under is 7-3 in the Colts last 10 games overall.

Bower's NFL Predictions: Manning vs Brady... what more could a football fan ask for? It will be fun to see the Patriots play the role of spoilers as they try not knock off the undefeated Colts. Just to be safe, my NFL pick for this match-up in week 10 NFL betting will be to take the Patriots on the road plus the points to the OVER. Vegas odds at Caesars sportsbook have the Indianapolis Colts -3 favorites in NFL betting against the New England Patriots with a total of 50.