March Madness Odds - (12) Arizona vs. (1) Louisville NCAA Odds

Top ranked Louisville will try and dispatch of the only double-digit seed to crash the Sweet Sixteen party as they face Arizona in March Madness odds on Friday night at 7:00pm EST on CBS.

Anything less than the Final Four would be a disappointment for Louisville but they are approaching Friday’s game in a good frame of mind.

"Even though it's a serious game, you want to win, but you can still smile while playing hard, trying to win the game," Louisville forward Terrence Williams said.

"So I want to be the rare guy that smiles all the time."

March Madness odds makers at SBGGlobal have Louisville -9 point favorites against Arizona in March Madness betting odds with a total of 139.

Louisville is 30-5 on the season and 21-14 against the spread. While Arizona doesn’t have the gaudy win-loss record of Louisville as they are 21-13 straight up they are almost identical against the spread at 20-13.

Get the latest NCAA Final odds and also view Michigan State vs North Carolina NCAA Final odds and predictions here.

The Wildcats are not expected to win this game against Louisville but don’t tell that to interim coach Russ Pennell. He was not even supposed to be coaching this team and now he has them in the Sweet Sixteen.

"When I signed on to work at the University of Arizona, I was hoping we'd be in the Sweet 16, but I had no idea that I would be the head coach," he said.

"The great thing about life, in general, is that it can change quickly. Sometimes it's for the best, and this year it's been that for me."

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Vegas odds at the MGM Mirage sportsbook have Louisville -9 point favorites in college basketball odds against Arizona with a betting total of 139.5 OVER -115.

Arizona vs Louisville March Madness Odds and Betting Stats

The Wildcats are 8-2 ATS in March Madness odds for their last 10 NCAA Tournament games. The Wildcats are 8-2 ATS in their last 10 non-conference games. The Wildcats are 11-4 ATS in their last 15 games overall. The Wildcats are 5-2 ATS in their last 7 games as an underdog.

The Cardinals are 6-2-1 ATS in March Madness odds for their last 9 NCAA Tournament games as a favorite. The Cardinals are 16-7 ATS in their last 23 games overall. The Cardinals are 0-4 ATS in their last 4 non-conference games.

The Over is 6-0 in March Madness odds for the Wildcats last 6 NCAA Tournament games as an underdog. The Over is 5-1 in the Wildcats last 6 non-conference games. The Over is 5-1-1 in the Wildcats last 7 vs. the Big East. The Over is 11-4 in the Wildcats last 15 overall.

The Under is 5-2 in the Cardinals last 7 neutral site games. The Under is 13-6-1 in the Cardinals last 20 non-conference games.

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