San Francisco 49ers at Arizona Cardinals Odds - 49ers vs Cardinals Betting

The NFC West takes the spotlight on Monday Night Football this week at 8:35pm EST on ESPN as the Arizona Cardinals (5-3) host the San Francisco 49ers (2-6). Odds makers have the Cardinals -9.5 point favorites at home in NFL odds against the 49ers with a total of 46.5. The Cardinals have done their part this season going 5-3 but the 49ers have not, going 2-6. The Cardinals are the only team in the NFC West with a winning record and they are heavily favored on Monday to notch another victory.

The Cardinals have an explosive offense led by quarterback Kurt Warner and a plethora of weapons including Anquan Boldin, Larry Fitzergald and rookie running back Tim Hightower. "We're excited about where we are as a team," head coach Ken Whisenhunt said. "We realize that we have a chance. But we also understand that last year at this time there were teams that were 6-2 that didn't even sniff the playoffs. I think taking that approach is going to keep us grounded. ... We've got only half the season behind us." Vegas NFL odds at the Wynn sportsbook have the Cardinals -9.5 point NFL betting favorites with a total of 46 in Week 10 odds.

The 49ers have struggled through the NFL schedule but at least they are entertaining again thanks to interim head coach Mike Singletary. He has made it clear to his team that things must change. One of his first changes was to bench tight end Vernon Davis and he will make another change this week starting Shaun Hill at quarterback. The 49ers will have to score on Monday to have a chance since the Cardinals are leading the NFL in scoring at 29.3 points per game.

San Francisco 49ers at Arizona Cardinals Betting Stats

The 49ers are 2-5 ATS in NFL odds for their last 7 vs. the NFC West. The 49ers are 1-4 ATS in their last 5 Monday games. The 49ers are 2-8 ATS in NFL odds for their last 10 road games. The 49ers are 1-6 ATS vs. a team with a winning record. The 49ers are 0-4 ATS in NFL odds for their last 4 games on grass. The 49ers are 0-5 ATS in their last 5 games overall. The 49ers are 2-5 ATS in NFL odds for the last 7 meetings between the two teams but the underdog in this series is 4-1 ATS in the last 5 meetings and the road team is 6-0 ATS in NFL odds for the last 6 meetings. The Cardinals are 4-0 ATS in their last 4 games overall.

The Cardinals are 4-0 ATS in NFL odds for their last 4 home games. The Cardinals are 8-3 ATS in their last 11 vs. NFC West. The Cardinals are 5-2 ATS in NFL odds for their last 7 games in November. The Under is 7-1 in the 49ers last 8 games in NFL betting for November. The Under is 10-4 in the 49ers last 14 vs. the NFC West. The Over is 5-0 in NFL betting for the Cardinals last 5 home games. The Over is 22-8 in the Cardinals last 30 games overall. The Over is 8-3 in NFL betting for the Cardinals last 11 vs. the NFC West. The Over is 4-0 in the last 4 meetings in Arizona between the two teams.