Indianapolis Colts at Pittsburgh Steelers Odds - Colts vs Steelers Betting

The Pittsburgh Steelers (6-2) proved last week they can win even without their starting quarterback as backup Byron Leftwich led them to a 23-6 win over the Washington Redskins after Ben Roethlisberger left with a shoulder injury. The status of Roethlisberger is up in the air for Sunday’s game against the Indianapolis Colts (4-4) at 4:15pm EST on CBS. The Steelers should still be favored at home, regardless of who is at quarterback. Odds makers have the Steelers -3.5 point favorites at home in NFL odds against the Colts with a total of 39.

The Colts rebounded last week with a big win against New England as Peyton Manning went 21-for-29 for 254 yards and two touchdowns in the 18-15 win. "It's a big win," Manning said, "It's important what we do with this. It sure would be nice to build off this, try to keep winning, get some kind of streak or some kind of rhythm established, but it doesn't get any easier from here on out." Vegas NFL odds at Caesars sportsbook have the Steelers -3 point NFL betting favorites with a total of 39.5 in Week 10 odds. Manning will be facing the #1 ranked defense in the NFL on Sunday night. The Steelers are allowing just 234.1 yards per game.

"Pittsburgh has a unique style of defense because of the players they have," Manning said. "They do things nobody else can do because of the players they have. You don't see anybody running wide open. You don't see a busted assignment. They truly make you execute and do your job." Indianapolis has had very little success at Pittsburgh in the past. They are 1-9 in the last 10 meetings at Pittsburgh on the NFL schedule.

Indianapolis Colts at Pittsburgh Steelers Betting Stats

The Colts are 3-7 ATS in NFL odds for their last 10 games overall. The Colts are 1-4 ATS in NFL odds for their last 5 games in Week 10. The Steelers are 4-1 ATS in NFL odds for their last 5 games in Week 10. The Steelers are 3-7-1 ATS in NFL odds for their last 11 games in November. The Over is 10-2 in NFL betting for the Colts last 12 games in Week 10. The Under is 8-2 in the Colts last 10 games in November. The Over is 5-2 in NFL betting for the Colts last 7 road games. The Over is 7-1 in NFL betting for the Steelers last 8 vs. the AFC. The Over is 5-1 in NFL betting for the Steelers last 6 games in Week 10. The Over is 37-14-2 in the Steelers last 53 home games. The Over is 7-3 in NFL betting for the Steelers last 10 games on grass.